Namhlanje ndifuna ukukubonisa umsebenzi owenziwe yinjineli yaseMexico URodrigo lozano, Umfundi okhoyo ngoku wobugqirha kwiYunivesithi yaseWollongong (Australia) oye wakwazi ukuyila nokuvelisa nge-3D ukushicilela akukho nto ingaphantsi kobuchopho obuncinci bokufunda ngokuziphatha kwee-neurons zezifo ezithile zobuchopho okanye zabantu Abasebenzisi beziyobisi.
Ukuqhuba uvavanyo lokuqala kule projekthi inzima, kubonakala ukuba injineli igqibe kwelokuba yenze isigqibo Yenza imodeli yobuchopho obuncinci usebenzisa ubuchwephesha bokushicilela kwe-3D kunye noyilo. Kuyo, ii-neurons zeempuku zabekwa kumaleko ahlukeneyo emodeli ekwaziyo ukusinda kangangeentsuku ezilishumi esenza zonke iinkqubo zonxibelelwano kwaye kubonakala ukuba akukho monakalo.
Benza ubuchopho obuncinci apho ii-neurons zinokuphila ukuya kwiintsuku ezili-10 zisenza yonke imisebenzi yazo yendalo.
Njengoko kuchaziwe yeyakho URodrigo lozano:
I-cortical neurons engafakwanga evela kwiimpuku ze-embryonic zifakwe kwi-polymer hydrogel ebizwa ngokuba yi-gellan gua, enemvelaphi yendalo kwaye ivumela ukudala ukumiswa kweeseli zibizwa 'bio-inki'
Malunga nezinto esizixelelwe ngentla apha, kufanele ukuba kuqatshelwe ukuba oku kuvela indleko ephantsi y iyahambelana nomzimba womntu kuba inyibilika ngokwaneleyo ukuvumela izakhamzimba kunye nezinto ezilahliweyo ezenziwe ziiseli ngokwazo ukuba zidlule kuzo. Kananjalo, le nto inepropathi eyomeleleyo ngokufanelekileyo kubushushu begumbi ngelixa ibonisa indawo ukuba inokuthi iguqulwe ngekhemikhali kunye neepeptides ezinje ngokuba yiRGD.
Njengeenkcukacha zokugqibela, phawula ukuba enkosi kulwakhiwo lwesiseko soku ingqondo encinci kunye nokusetyenziswa kwale intsha ihydrogel ii-neurons zikwazile ukukhula nokwandisa unxibelelwano lwazo kumakhulu ee-microns. Ndiyabulela kule nto, emva kweentsuku ezilishumi ukusukela ekuqaleni kovavanyo, kwafunyaniswa ukuba ubume babuneempawu ezifanayo kwiiseli zecortical esele ikhulile kwaye nokuba ii-neurons zikwazile ukwenza ulwakhiwo olucwangcisiweyo olufana necortex yobuchopho.